Stuart runs a struggling comic-book store. But on a slow Tuesday, he breaks a device that was built by Leonard & Sheldon. The Universe doesn't end with a bang, but starts glitching badly - birds start to fly backward, the same day repeats, and Stuart’s girlfriend, Denise, forgets his name.

Now, it’s upon Stuart to fix what he broke. He tried to rope in the only people available to help. Denise, who is furious but loyal. Bert, a geologist convinced the answer lies underground. And Barry Kripke, a quantum physicist who won't stop reminding everyone he is smarter than all of them combined.

The mismatched team chases half baked theories through sinkholes, storage units, and one deeply awkward group therapy session. They don't fully fix the universe, but they fix each other a little. According to the show's title, this might be the best they will ever manage.